Therapeutic approaches to inflammation in neurodegenerative disease.
Identifieur interne : 002425 ( Main/Exploration ); précédent : 002424; suivant : 002426Therapeutic approaches to inflammation in neurodegenerative disease.
Auteurs : Andis Klegeris [Canada] ; Edith G. Mcgeer ; Patrick L. McgeerSource :
- Current opinion in neurology [ 1350-7540 ] ; 2007.
English descriptors
- KwdEn :
- Brain (drug effects), Brain (immunology), Brain (physiopathology), Encephalitis (drug therapy), Encephalitis (immunology), Encephalitis (physiopathology), Gliosis (drug therapy), Gliosis (immunology), Gliosis (physiopathology), Humans, Immunologic Factors (pharmacology), Immunologic Factors (therapeutic use), Immunotherapy (methods), Immunotherapy (trends), Microglia (drug effects), Microglia (immunology), Parkinson Disease (drug therapy), Parkinson Disease (immunology), Parkinson Disease (physiopathology), Receptors, Cytokine (drug effects), Receptors, Cytokine (immunology), alpha-Synuclein (immunology).
- MESH :
- chemical , drug effects : Receptors, Cytokine.
- chemical , immunology : Receptors, Cytokine, alpha-Synuclein.
- chemical , pharmacology : Immunologic Factors.
- drug effects : Brain, Microglia.
- drug therapy : Encephalitis, Gliosis, Parkinson Disease.
- immunology : Brain, Encephalitis, Gliosis, Microglia, Parkinson Disease.
- methods : Immunotherapy.
- physiopathology : Brain, Encephalitis, Gliosis, Parkinson Disease.
- chemical , therapeutic use : Immunologic Factors.
- trends : Immunotherapy.
- Humans.
Abstract
According to the neuroinflammatory hypothesis of neurodegenerative diseases, drugs with an anti-inflammatory mode of action should slow the disease progression. Here we review recent advances in our understanding of one such disorder, Parkinson's disease, in which anti-inflammatory drugs are now becoming a new therapeutic focus.
DOI: 10.1097/WCO.0b013e3280adc943
PubMed: 17495632
Affiliations:
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Le document en format XML
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